RSS | Sepsi

Monitoraggio costante delle ultime pubblicazioni su sepsi, shock settico e infezioni gravi tramite feed RSS da PubMed. Una risorsa utile per rimanere aggiornati su diagnosi precoce, protocolli terapeutici, strategie di gestione e novità farmacologiche nella lotta contro una delle emergenze più critiche in ambito medico.

Sepsi

Validation of the updated sequential organ failure assessment (SOFA)-2 score in emergency department septic shock 3 Settembre 2026
CONCLUSION: Among ED patients with septic shock, SOFA-2 showed modestly improved discrimination, closer agreement between predicted and observed in-hospital mortality with lower overall prediction error, and more favorable continuous reclassification metrics compared with SOFA-1. These findings support the external validation of SOFA-2 in this population and warrant further evaluation in diverse ED settings.
Sejoong Ahn
Interhospital Transfer Patients With Necrotizing Soft Tissue Infections: An Evaluation of the Role for Pretransport Operation 2 Settembre 2026
CONCLUSION: Among transferred NSTI patients, mortality did not differ between PRE and the remainder of the cohort. PRE patients had longer hospital stays and higher healthcare charges, possibly due to worse physiology or more complex wounds.
Hans V Strobl
Comparative Prognostic Performance of qSOFA and SOFA in Emergency Department Patients With Established Septic Shock 28 Agosto 2026
CONCLUSION: In patients with established septic shock according to Sepsis-3 criteria, SOFA outperformed qSOFA in mortality risk stratification. qSOFA may be useful for rapid bedside screening but should not replace the comprehensive prognostic assessment provided by SOFA.
Xue Liu
Impact of the Korean Medical-Political Conflict on Septic Shock Care in the Emergency Department: A Retrospective Single-Center Clinical Analysis 27 Agosto 2026
Background and Objectives: The 2024 Korean medical-political conflict caused the mass resignation of trainee physicians, raising concerns about the quality of care for time-critical emergencies. This study aimed to assess the impact of workforce disruptions on the management and outcomes of adults presenting to the emergency department (ED) with septic shock. Materials and Methods: This […]
Seongmun Kang
Mortality prediction using the Shock Index and Modified Shock Index in the Emergency Department 27 Agosto 2026
CONCLUSIONS: the Modified Shock Index demonstrated greater predictive ability for mortality, suggesting its usefulness in nursing clinical practice.
Karoline Maciel Lopes
Early Identification of a Cytokine-Low Immune Phenotype in Suspected Sepsis Using a Point-of-Care Whole-Blood TNF-α Release Assay 26 Agosto 2026
CONCLUSIONS: A TARA low-response status was independently associated with an early circulating cytokine-low phenotype defined without reference to TARA or outcomes, providing information complementary to routine biomarkers and clinical severity scores. These exploratory findings support TARA as a complementary functional immune readout but require external validation and clinical-impact evaluation.
Erika P Plata-Menchaca
Prognostic value of the lactate-to-albumin ratio in adult sepsis: An updated systematic review of prognostic evidence 26 Agosto 2026
CONCLUSIONS: Higher LAR is associated with mortality in adult sepsis and may provide complementary prognostic information. However, clinical and methodological heterogeneity precludes a universal cut-off or single pooled adjusted effect. Standardized prospective multicenter studies are required before routine clinical implementation.
Zeynep Eker Kurt
Recommendations for the initial management of septic shock in children 25 Agosto 2026
We present an update on recommendations for managing septic shock in the emergency department during the "golden hour," highlighting the importance of early recognition and rapid implementation of therapeutic measures to reduce morbidity and mortality. It includes specific diagnostic criteria (the Phoenix Sepsis Scale), which improve the identification of sepsis and septic shock, although their […]
Guillermo Kohn-Loncarica
Effectiveness of the "Golden Hour" program in preventing sepsis in pediatric patients with acute lymphoblastic leukemia 24 Agosto 2026
CONCLUSIONES: La administración de antibiótico dentro de los primeros 60 minutos se asoció con menor incidencia de sepsis en pacientes con leucemia linfoblástica aguda.
Mónica V Cárdenas-Monsibaiz
Prognostic accuracy of SPEED, NEWS, and NEWS-L for predicting 28-day mortality in geriatric sepsis: A prospective study 22 Agosto 2026
CONCLUSIONS: All evaluated scoring systems demonstrated only moderate prognostic performance for predicting 28-day mortality in geriatric patients with sepsis, and no statistically significant differences were observed among SOFA, NEWS, NEWS-L, and SPEED. These findings suggest that currently available bedside prognostic tools may have limited discriminatory ability in older adults and highlight the need for the […]
Orhan İnaltekin
Predictive Performance of Sepsis Scoring Tools for In-Hospital Mortality Among Patients With Suspected Sepsis Presenting to the Colonial War Memorial Hospital Emergency Department, Fiji 21 Agosto 2026
CONCLUSIONS: NEWS demonstrated higher prognostic accuracy compared to qSOFA and SIRS in predicting in-hospital mortality for suspected sepsis patients. Our study provides a benchmark for future ED-based sepsis research in the Pacific.
Isaac V Singh
Diagnostic accuracy and severity prediction of monocyte distribution width in sepsis: a retrospective study from the United Arab Emirates 20 Agosto 2026
INTRODUCTION: Monocyte distribution width (MDW) is an early sepsis biomarker derived from the routine complete blood count. Existing evidence is overwhelmingly from European, North American, and East Asian cohorts, with no published Middle Eastern data. We evaluated the diagnostic value of MDW for sepsis identification in a United Arab Emirates (UAE) tertiary care population, comparing […]
Uzma Sabahat
An Unusual Suspect in a Case of Fungal Necrotizing Soft Tissue Infection 18 Agosto 2026
Necrotizing soft tissue infection (NSTI) is a rapidly progressive and potentially fatal infection that is most commonly bacterial in origin but can also be fungal. We present the case of a 79-year-old woman who developed NSTI after gastrostomy tube (G-tube) manipulation. She presented to the emergency department (ED) with abdominal pain and inflammation, and imaging […]
Erin N Burns
Beta-lactam antibiotics have immunomodulatory effects in vitro, including changes consistent with sepsis-induced immunosuppression 18 Agosto 2026
CONCLUSION: Beta-lactam antibiotics have immunomodulatory effects in vitro, including changes consistent with sepsis-induced immunosuppression at clinically relevant doses. Further work is required to determine the mechanisms underpinning these observations and clinical implications, which may have significant clinical implications on the type and duration of antibiotics administered, and highlight the need for therapeutic antibiotic monitoring.
Timothy Arthur Chandos Snow
Evolution of Sepsis Management in the Emergency Department: From Early Goal-Directed Therapy to Personalized Resuscitation 17 Agosto 2026
Sepsis remains a leading cause of morbidity and mortality worldwide and represents a major challenge in emergency medicine. Early recognition and timely intervention are critical determinants of patient outcomes. The introduction of early goal-directed therapy (EGDT) in 2001 transformed sepsis management by promoting protocolized hemodynamic resuscitation during the initial hours of care. However, subsequent evidence […]
Naser Mohamad Mansoor
First Case of Candidemia With Fluconazole-Resistant <em>Candida albicans</em> and Y132H Mutations in <em>ERG11</em> Gene From Pakistan 14 Agosto 2026
Candida albicans is one of the critical priority fungal pathogens as classified by the World Health Organization. Fluconazole resistance in C. albicans is increasingly being reported from different parts of the world. The epidemiology of antifungal resistance in Pakistan is evolving. While fluconazole resistance is rarely reported in invasive candidemia, it has been identified in […]
Nosheen Nasir
Midgut Volvulus with Necrosis: A Complication of Endometriosis 12 Agosto 2026
CONCLUSION: This case illustrates a rare and severe presentation of intestinal endometriosis mimicking Crohn's disease, progressing to life-threatening bowel necrosis. It underscores the diagnostic challenges of endometriosis and the critical role of multidisciplinary care in optimizing outcomes for complex cases.
Yasmin Abozenah
Context-specific predictors of mortality and the performance of paediatric sepsis scores in Tanzanian children: a secondary analysis of a prospective cohort study 7 Agosto 2026
CONCLUSIONS: Multiple clinical and sociodemographic factors were independently associated with mortality in children with sepsis. LODS demonstrated high sensitivity, while BqSOFA and PSS demonstrated high specificity; the scores' discriminative ability for mortality was not statistically significant. The identification of simple risk factors and moderately performing clinical scores provides a valuable opportunity to develop context-specific risk […]
Abigail Sorensen
Prognostic value and clinical net benefit of global longitudinal strain in sepsis: a prospective study with internal bootstrap validation 6 Agosto 2026
CONCLUSION: STE-derived GLS is a highly sensitive, relatively load-independent marker of early myocardial dysfunction in sepsis, significantly outperforming LVEF in predicting 28-day mortality. The validated GLS-SOFA nomogram and decision curve models provide a practical, high-yield tool to enhance risk stratification and guide early personalized hemodynamic resuscitation in emergency settings.
Xuan Dai
A fatal ascending spinal subdural empyema due to Streptococcus intermedius in a socially vulnerable patient: Forensic perspectives on diagnostic delay and implicit bias 6 Agosto 2026
A fatal case of ascending spinal and cranial subdural empyema (SDE) caused by Streptococcus intermedius in a socially vulnerable 63-year-old man with repeated emergency department (ED) admissions is reported. Despite persistent lower back pain and neurological symptoms, advanced neuroimaging and additional clinical and laboratory evaluation were delayed, ultimately leading to septic shock and multi-organ failure. […]
Loredana Buscemi